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KMID : 0357920030370050320
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Korean Journal of Pathology
2003 Volume.37 No. 5 p.320 ~ p.324
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Studies of CD44s and CD44v6 Expressions and Correlation with Clinicopathologic Parameters in Gastric Carcinoma
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Li Zhu-Ho
Lin Zhen-Hua
Jeon Ho-Jong
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Abstract
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Backgroud: The aim of this study is to elucidate the relationship between CD44s and CD44v6 expression level and the biological characteristics of a gastric carcinoma.
Methods: CD44s and CD44v6 expression was investigated in 56 gastric carcinomas, 18 dysplasias, and 22 normal mucosae by immunohischemical staining.
Results: The CD44s and CD44v6 expression rates in gastric carcinomas, dysplasi, and normal mucosae were 80.3% and 83.9%, 72.2% and 77.8% and 13.6% and 4.5%, respectively. Statistical analysis showed significant difference after comparing a gastric carcinomas and dysplasia to the normal mucosae (p<0.001). The CD44s and CD44v6 expression rate in the cases with invasion to the muscle proper and serosa were 60.7% and 57.1%, and 82.4% and 88.2%, respectively. Both showed a significant statistical difference compared to the expression rates in the cases with invasion to the mucosae and submucosae. The CD44s and CD44v6 expression rates in gastric carcinomas with a lymph node metastasis (p<0.001 and (p<0.01, respectively). CD44s and CD44v6 were also expressed in the normal vassal cells around gastric carcinomas.
Conclusions: The CD44s and CD44v6 expression showed a significant relationship with gastric cardinogenesis, toward an aggressive biological behavior.
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KEYWORD
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Gastric Carcinoma, Dysplasia, CD44s, CD44v6
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